Aminoglycosides: Activity and Resistance

Aminoglycosides: activity and resistance.

Aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable properties for the treatment of lifethreatening infections (28). Their history begins in 1944 with streptomycin and was thereafter marked by the successive introduction of a series of milestone compounds (kanamycin, gentamicin, and tobramycin) which definitively established the usefulness of this class of antibiot...

Specific and non-specific resistance to aminoglycosides in Escherichia coli.

The turbidimetric responses of a strain of Escherichia coli K12 to gentamicin and tobramycin were investigated. Both agents showed antibacterial activity below the conventionally measured minimum inhibitory concentration, but exposure to such subinhibitory concentrations of either agent generated a bacterial population which was able to grow in previously inhibitory concentrations at a rate equ...

Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.

High Level Resistance to Aminoglycosides in Urinary Isolates of Enterococci

Sir, Enterococci have become important nosocomial pathogens world-wide and are associated with a high mortality. The treatment of these infections poses a great challenge due to the inherent resistance of Enterococci to many antibiotics.[1] Infections by Enterococci have traditionally been treated with cell wall active agents in combination with an aminoglycoside; however, the emergence of high...

Anaerobic resistance of clinical isolates of Staphylococcus aureus to aminoglycosides.

The anaerobic minimum inhibitory concentration of six aminoglycosides (amikacin, gentamicin, kanamycin, netilmicin, sisomicin, and tobramycin) averaged over 10-fold greater than the aerobic minimum inhibitory concentration for 50 clinical isolates of Staphylococcus aureus. Cultures from osteomyelitis and blood generally showed a somewhat greater increase in minimum inhibitory concentration due ...